The Regulation of Apoptosis by the Mitochondria and ...

Object Details

View

Title Information
The Regulation of Apoptosis by the Mitochondria and the Endoplasmic Reticulum

Name:Personal
Ryan Griesbach
Role :Text(marcrelator)
creator

Name:Personal
Dr. Peter Thorsness
Role :Text(marcrelator)
creator

typeOfResource
text
genre
Powerpoint/PDF
Origin Information Place
Laramie, Wyoming

University of Wyoming
(keyDate="yes")
4/24/2010

Physical Description
born digital

abstract
Cells throughout biology maintain strict regulation of growth and cellular integrity through the control of apoptosis, or planned cell death. For many years now, it has been known that the mitochondria have played an integral role in the signaling pathway associated with apoptosis (Chen, 2009; Nigam et al., 2009). However, new evidence has arisen concerning several aspects of this signaling pathway. First, it has been shown that cancer cells change the roles of mitochondrial proteins in order to maintain mitochondrial membrane potential (??m) and thus avoid starting the apoptotic cascade that would otherwise take place. Recent studies have shown that by attacking the protein necessary for maintaining the membrane potential, normal cell regulation would resume and cancerous growth could be stopped. Likewise, new research has shown that the endoplasmic reticulum (ER) might have some roles in the apoptosis signaling cascade (Wang et al., 2009). Here we report that human versions of the transporter proteins used in maintaining ??m by cancerous cells can be inserted into Saccharomyces cerevisiae and thus tested for a chemical that could possibly impede these proteins ability to function. Likewise, we have developed a procedure for determining the mitochondrial-ER association in Saccharomyces cerevisiae, and possible linkage by mitochondrial outer membrane (MOM) proteins.
note
From - Undergraduate Research Day 2010 - Celebration of Research - Abstracts
Subject
Undergraduate Research Day

Related Item:Host Title Information
Undergraduate Research Day 2010

Location (usage="primary display")
http://hdl.handle.net/10176/wyu:760

accessCondition:useAndReproduction
http://digital.uwyo.edu/copyright.htm