Hypertrophic Rat Hearts Transition From ...

Object Details

View

Title Information
Hypertrophic Rat Hearts Transition From Hyper-functional to Hypo-functional Within One Month of Severe Iron Deficiency

Name:Personal
Kelsey Dockter
Role :Text(marcrelator)
creator

Name:Personal
Alix Boynton
Role :Text(marcrelator)
creator

Name:Personal
Bethelhem Almaw
Role :Text(marcrelator)
creator

typeOfResource
text
genre
Powerpoint/PDF
Origin Information Place
Laramie, Wyoming

University of Wyoming
(keyDate="yes")
4/24/2010

Physical Description
born digital

abstract
Iron deficiency is known to induce cardiac hypertrophy (heart enlargement), hypothesized to result from chronic sympathetic nervous system stimulation. Previous work (Dong et al., 2005) demonstrated cardiac apoptosis from 12 weeks of iron deficiency, but little is known about the ability of the heart to generate force at early stages of iron deficiency. We hypothesized that chronic sympathetic stimulation from iron deficiency would result in an increase in left ventricular pressure after two weeks, but a reduced ability to generate pressure after four weeks of iron deficiency. Methods: Rats were placed on an iron deficient or iron replete diet for two or four weeks, after which their hearts were excised and subjected to a Langendorff isolated heart protocol. Left ventricular pressure was monitored by balloon catheter inserted through the left atrium, and flow was adjusted stepwise from 10-18 ml•min-1 of perfusion solution to create Starling’s Law of The Heart Curves. Results: Iron deficient hearts were shown to produce significantly increased left ventricular pressure after two weeks, but significantly less after four weeks of iron deficiency. Conclusion: Hypertrophic rat hearts transition from a hyper-functional pressure generation capacity to a hypo-functional capacity as iron deficiency progresses.
note
From - Undergraduate Research Day 2010 - Celebration of Research - Abstracts
Subject
Undergraduate Research Day

Related Item:Host Title Information
Undergraduate Research Day 2010

Location (usage="primary display")
http://hdl.handle.net/10176/wyu:735

accessCondition:useAndReproduction
http://digital.uwyo.edu/copyright.htm