Mapping Pain Pathways in the Spinal Cord of Mice

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Mapping Pain Pathways in the Spinal Cord of Mice

Name:Personal
Scicluna, Elise
Role :Text(marcrelator)
creator

Name:Personal
Woodbury, Dr.
Role :Text(marcrelator)
contributor

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still image
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Laramie, Wyoming

University of Wyoming
(keyDate="yes")
2009-05-18

Language:Text
eng

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born digtal

abstract
The project examined the sensory system that conveys information to the cerebral cortex and ultimately our conscious awareness of external stimuli. Mapping the spinal network and how it relays information to the thalamus was studied using mice. The substantia gelatinosa, the sensory integration center, is located in the spinal cord. It controls nociceptive and tactile transmission to the brain. Nociceptors and tactile receptors receive sensory information from the external environment and relay it to second order neurons located in the spinal cord. The substantia gelatinosa then projects the input to higher regions of the brain. Using mice, these spinal cord neurons can be mapped. In the experiments, mice were anesthetized and marker injections were made to find where the spino-thalamic neurons terminate. Surgical procedures were performed to make the injections, and the mice were allowed to rest for 6-7 days. Then, mice were sacrificed and their nervous tissue was preserved. The brain and spinal cord of the mice were detached and partitioned to tag the neurons. The neurons that conveyed the marker to their cell bodies were mapped according to location in the spinal cord. Understanding this pathway will beneficial because mice are becoming the preferred model for pain research.
note
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
Subject
spinal cord

Subject
Nociceptors

Subject
substantia gelatinosa

Related Item:series Title Information
Undergrauate Research Day 2009

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http://digital.uwyo.edu/copyright.htm
Record Information languageOfCataloging :Text(ISO639-2B)
English
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eng