The Role of Endogenous MIF on Ischemic AMPK Activation

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The Role of Endogenous MIF on Ischemic AMPK Activation

Name:Personal
Poulos, Garrett
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creator

Name:Personal
Li, Dr. Ji
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contributor

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still image
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Laramie, Wyoming

University of Wyoming
(keyDate="yes")
2009-05-15

Language:Text
eng

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abstract
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is increased in the plasma of patients with myocardial infarction and in animal hearts following ischemic injury. A known important regulator of metabolism in striated muscle is AMP-activated protein kinase (AMPK). Recent information suggests that cardiac MIF may play a role in the activation of AMPK and that human cells with a low expression of the MIF gene promoter have impaired activation of AMPK during hypoxia that is corrected by exogenous MIF. An understanding of this as it pertains to the regulation of AMPK could have implications for potential pharmacological treatments for ischemic myocardium. This study examined the role of endogenous MIF on ischemic AMPK activation. This was done by utilizing mice unable to create endogenous MIF. Isolated hearts from these mice were subjected to various durations of control perfusion or global ischemia with or without reperfusion and immunoblot analysis was performed to assess AMPK expression. These experiments are still in progress and full results are not available, but it seems likely from available results that AMPK activation is influenced by MIF.
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From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
Subject
AMP-activated protein kinase (AMPK)

Subject
cardiac MIF

Related Item:series Title Information
Undergrauate Research Day 2009

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http://digital.uwyo.edu/copyright.htm
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English
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eng