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Cisplatin compromises the ultrastructure of ...

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Cisplatin compromises the ultrastructure of mitochondria and mechanical function of cardiomyocytes

Name:Personal
Jones, Kyla Role :Text(marcrelator)
creator

Name:Personal
Ren, Dr. Jun Role :Text(marcrelator)
contributor

Name:Personal
Ma, Dr. Heng Role :Text(marcrelator)
contributor

typeOfResource
still image genre
Origin Information Place
Laramie, Wyoming
University of Wyoming (keyDate="yes")
2009-05-14

Language:Text
eng

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abstract
Today, cisplatin is a chemotherapeutic agent used to treat various types of tumors. Treatment with this drug has been effective against numerous malignancies, including those of the lung, head and neck, and especially genito-urinary system. Despite the effectiveness of cisplatin, it has been shown to have toxic side effects. The focus of this research was to determine the mechanism of cardiotoxicity correlated with the medication. Throughout this experiment, research was done on C57 male mice. They were treated with Cisplatin (10 mg/kg/day i.v.) or control (0.9% NaCl) for one week. Cardiac tissue was collected one week later for analysis. Various experiments were performed, including: mouse heart perfusion, cardiomyocyte isolation, measurement of cell shortening and relengthening, and western blot analysis. The results collectively illustrated that cisplatin is harmful to cardiomyocytes. The heart to body weight ratio was slightly decreased, while the peak shortening amplitude and maximal velocity of shortening/relengthening were significantly depressed. Results also demonstrated that cisplatin compromises the mitochondrial membrane and activates the ER stress response. This damage leads to induced apoptosis. From this information, we can conclude that treatment with cisplatin has various mechanisms in which it damages cardiomyocytes and results in cardiotoxicity. note
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
Subject
cisplatin

Subject
malignancies

Subject
cardiotoxicity

Related Item:series Title Information
Undergrauate Research Day 2009

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http://digital.uwyo.edu/copyright.htm
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English :Code(ISO639-2B)
eng