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Cytoarchitectonic and Immunohistological Profile of ...

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Cytoarchitectonic and Immunohistological Profile of FMR1-KO Mice in the Posterior Piriform Cortex

Name:Personal
Felton, Tyler Role :Text(marcrelator)
creator

Name:Personal
Young, Andrew Role :Text(marcrelator)
creator

Name:Personal
Zhang, Chunzhao Role :Text(marcrelator)
creator

Name:Personal
Sun, Qian-Quan Role :Text(marcrelator)
creator

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still image genre
Origin Information Place
Laramie, Wyoming
University of Wyoming (keyDate="yes")
2009-05-13

Language:Text
eng

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born digtal

abstract
In this study we examined cytoarchitectonic and immunohistological profile of GABAergic neurons in the posterior piriform cortex. Taking advantage of transgenic mice in which GABAergic neurons express green fluorescent proteins (GFP), we studied subtype specific expression of cellular markers in GABAergic circuits and their developmental profile. In the part of the study, several neuronal markers, including calcium binding proteins, voltage-gated potassium channels, glutamate receptors, were examined in GAD67-GFP and GAD65-GFP mice. The results of these experiments support the idea that GABAergic cells of the piriform cortex are composed of multiple subtypes with combinatory expression of different neuronal markers. In the second part of the study, we observed the longevity of GAD67-GFP and GAD65-GFP cells. Mice of six different age groups were used including: 1 month 12 days, 1 month 22 days, 3 month, 6 month, 1 year 22 days, and 2 year. The results showed that the density of GAD65-GFP neurons in the posterior piriform cortex and cell body area maintain a fairly constant level throughout life, with the cell body area peaking at 4-6 months of age. Also, the majority of cells found in layer II and the ratio of layer II cells/total GAD65-GFP cells remains constant throughout life. These results 1) provide detailed information regarding cell-type specific expression of cellular markers; 2) provide evidence that GABAergic neurons in the posterior piriform cortex maintain stable morphological and cytoarchitechtonic properties from 1 month to 2 years of age in mice. note
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
Subject
cytoarchitectonic profile

Subject
immunohistological profile

Subject
GABAergic neurons

Related Item:series Title Information
Undergrauate Research Day 2009

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eng