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Effects of Deslorelin on Murine Cardiac Tissue

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Effects of Deslorelin on Murine Cardiac Tissue

Name:Personal
Talbott, Heather Role :Text(marcrelator)
creator

Name:Personal
Department of Zoology and Physiology; Dr. Donal Skinner Role :Text(marcrelator)
contributor

typeOfResource
still image genre
Powerpoint/Pdf
Origin Information Place
Laramie, Wyoming
University of Wyoming (keyDate="yes")
2008-04-23

Language:Text
eng

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born digital

abstract
Prostate cancer, a problem for some men is sometimes treated with a gondotropin releasing hormone (GnRH) agonist, such as deslorelin. GnRH agonists work by desensitizing GnRH receptors and reducing levels of many reproductive hormones. Testosterone, one hormone regulated by GnRH, has been implicated in fueling prostate cancer growth, and reduction of testosterone levels by GnRH agonists is a treatment for prostate cancer. There are some problems associated with this treatment; a recent study reported cardiac events occurred at a higher rate for men taking GnRH agonists compared to other treatments. In this study we will examine the effects of deslorelin on murine cardiac tissue. We will use reverse transcriptase PCR to examine GnRH and GnRH receptor mRNA levels in male mice that have been administered deslorelin. Immunohistochemistry will also be used to visualize cells in the cardiac tissue that produce and are affected by GnRH. We believe that the murine heart has its own GnRH system independent from the GnRH axis present in the brain, and that GnRH agonists have significant negative effects on the heart. This has significant importance in the treatment of prostate cancer with GnRH agonists, especially to men with increased risk of cardiac problems. note
From - Undergraduate Research Day 2008 - Celebration of Research - Abstracts
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TBD

Related Item:series Title Information
Undergrauate Research Day 2008

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http://digital.uwyo.edu/copyright.htm
Record Information languageOfCataloging :Text(ISO639-2B)
English :Code(ISO639-2B)
eng