Gonadotropin Releasing Hormone Receptor mRNA ...

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Title Information
Gonadotropin Releasing Hormone Receptor mRNA Expression in the Murine Cerebellum

Name:Personal
Talbott, Heather
Role :Text(marcrelator)
creator

Name:Personal
Department of Zoology and Physiology; Dr. Donal Skinner
Role :Text(marcrelator)
contributor

typeOfResource
still image
genre
Powerpoint/Pdf
Origin Information Place
Laramie, Wyoming

University of Wyoming
(keyDate="yes")
2008-04-23

Language:Text
eng

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born digital

abstract
Reproduction is driven by gonadotropin releasing hormone, GnRH, which is released from the hypothalamus and stimulates the release of FSH (follicle stimulating hormone) and LH (luteinizing hormone) from the anterior pituitary. Immunohistochemistry and western blot analysis in mice provides some evidence that the GnRH protein exists within some cells of the cerebellum. To verify this evidence and provide further support for this discovery reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to determine if the mRNA coding for the GnRH receptor is present in the murine cerebellum. Results show a very low concentration of GnRH receptor mRNA. This could be due to degradation of the RNA, or it is possible that each strand of RNA is used multiple times to produce many of the GnRH receptor proteins. This has implications in some reproductive diseases, most notably Gordon Holmes syndrome, characterized by reproductive incompetence and cerebellar ataxia. A defect in the GnRH receptor could possibly have drastic influences on cells involved with movement and coordination within the cerebellum. Further investigation of the influence of GnRH on the cerebellum would be needed to help provide the link between the symptoms of Gordon Holmes disease.
note
From - Undergraduate Research Day 2008 - Celebration of Research - Abstracts
Subject
Luteinizing hormone releasing hormone--Receptors; Cerebellum--Diseases--Research

Related Item:series Title Information
Undergrauate Research Day 2008

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http://digital.uwyo.edu/copyright.htm
Record Information languageOfCataloging :Text(ISO639-2B)
English
:Code(ISO639-2B)
eng